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Journal of Disability Policy Studies, Vol. 18, No. 4, 230-244 (2008)
DOI: 10.1177/1044207307311532

Protecting People With Decisional Impairments and Legal Incapacity Against Biomedical Research Abuse

John H. Noble, Jr

State University of New York at Buffalo, jhnoble{at}verizon.net

Vera Hassner Sharav

Alliance for Human Research Protection, New York

Ethical and legal principles are provided for reviewing the ethics of recent cases of biomedical research abuse involving persons with decisional impairments or legal incapacity who were unable to understand the risks and benefits of the research to which they were subjected. Research abuse continues to occur despite guidance from the Nuremburg Code, the Declaration of Helsinki, the U.S. Belmont Report, extensive federal regulations governing human participant research, and several professional and disciplinary codes of ethics with which, the authors believe, the majority of researchers comply. Contributing to research abuse are weaknesses in the institutional review board and research ethics board review process; conflicting opinions about applicable ethical principles; mounting evidence of pervasive conflicts of interest; and dubious conflated research and marketing practices involving researchers, pharmaceutical and medical device manufacturers, and government research sponsors and regulatory agencies. Several recommendations are made to correct identifiable weaknesses and failures in the governance of biomedical research.

Key Words: research ethics • human participants abuse • decisional impairments • Nuremberg Code • institutional review boards • conflicts of interest

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